研究成果
研究成果
(2000年以降発表分)
Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S. Neuroprotective Mechanism of GDNF in Mesencephalic Neurons. J. Neurochem. 74: 1175-1184, 2000
Sawada H, Udaka F, Izumi Y, Nishinaka K, Kawakami H, Nakamura S, Kameyama M. Cerebral white matter lesions are not associated with apo E genotype but with age and female gender in Alzheimer’s disease. J. Neurol. Neurosurg. Psych. 68: 653-656, 2000
Sawada H, Ibi M, Kihara T, Urushitani M, Honda K, Nakanishi M, Akaike A, Shimohama S. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons. FASEB J. 14: 1202-1214, 2000
Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res. 60: 321-327, 2000
Urushitani M, Inoue R, Nakamizo T, Sawada H, Shibaski H, Shimohama S. Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons. J Neurosci. Res. 61: 443-448, 2000
Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S. Protection of cultured spinal motor neurons by estradiol. Neuroreport 11: 3493-3497, 2000
Urushitani M, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S. N-methyl-D-aspartate receptor-mediated mitochondrial Ca2+-overload in acute excitotoxic neuronal death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx. J. Neurosci. Res. 63: 377-387, 2001
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A. α7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block Aβ-amyloid-induced neurotoxicity. J. Biol. Chem. 276: 13541-13546, 2001
Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S. Akaike A. Protective effects of 1 α, 25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology 40:761-771, 2001
Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki S. Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J. Neurosci. Res. 64: 466-475, 2001
Nakamizo T, Inoue H, Udaka F, Oda M, Kawai M, Uemura K, Takahashi M, Nishinaka K, Sawada H, Kameyama M, Koyama T. Magnetic resonance imaging of primary spinal intramedullary lymphoma. J. Neuroimaging 12: 183-186, 2002
Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A, Shimohama S. Estradiol protects dopaminergic neurons in a MPP+ Parkinson’s disease model. Neuropharmacology 42: 1056-1064, 2002
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A. Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. J. Neurosci. Res. 70: 274-282, 2002
Udaka F, Sawada H, Kameyama M. White matter lesions and dementia: MRI-pathological correlation. Ann. N. Y. Acad. Sci. 977:411-415, 2002
Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibassaki H, Akaike A, Shimohama S. Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons. J. Neurosci. Res. 71: 485-495, 2003
Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport 14: 2425-2428, 2003
Inden M, Kondo J, Kitamura Y, Takata K, Tsuchiya D, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone. Biogenic Amines 17: 281-291, 2003
Shinde A, Nakano S, Kusaka H, Nakaya Y, Sawada H, Kohara N, Shibasaki H. Nucleolar characteristics of reducing bodies in reducing body myopahty. Acta Neuropathol. 107: 265-271, 2004
Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S. Proteasome mediates dopaminergic neuronal degeneration, and its inhibition cuases α-synuclein inclusions. J. Biol. Chem. 279: 10710-10719, 2004
Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S. BDNF is induced by wild-type α-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochem. Biophys. Res. Commun. 318: 113-118, 2004
Kanki R, Nakamizo T, Yamashita H, Kihara T, Sawada H, Uemura K, Kawamata J, Shibasaki H, Akaike A, Shimohama S. Effects of mitochondrial dysfunction on glutmate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. Brain Res. 1015: 73-81, 2004
Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S. Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. Biochem Biophys Res Commun. 325: 976-982, 2004
Inden M, Kondo JI, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. J Pharmacol. Sci. 97: 203-211, 2005
Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S. Cocaine and phenylephrine eye drop test for Parkinson disease. JAMA 293: 932-934, 2005
Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly J Neurosci Res 79: 849-860, 2005.
Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S. Stimulation of nicotinic acetylcholine receptors protects motor neurons. Biochem Biophys Res Commun 330: 1285-1289, 2005
Kume T, KawaiY, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A. Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons. Neurosci Lett 382: 199-202, 2005
Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S. Akaike A. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. J Neurosci Res 82: 126-137, 2005
Ueki Y, Mima T, Kotb MA, Sawada H, Saiki H, Ikeda A, Begum T, Reza F, Nagamine T, Fukuyama H. Altered plasticity of the human motor cortex in Parkinson’s disease. Ann Neurol 59: 60-71, 2006
Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimot H, Shimohama S. Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Intern Med 45: 135-140, 2006
Begum T, Ikeda A, Yoshioka A, Sawada H, Fukuyama H, Shibasaki H. Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia and transient hypoxemia. Intern Med 45: 823-826, 2006
Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: Relevance to Parkinson disease. J Biol Chem 282: 4364-72, 2007
Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity. Eur J Pharmacol 557: 132-140, 2007
Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura K, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashir R, Shimohama S. Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Pakrinson’s disease model. J Neurosci Res (in press)
Sawada H, Oeda T, Yamamoto K, Kitagawa N, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T. Diagnostic accuracy of cardiac metaiodobenzylguanidine (MIBG) scintigraphy in Parkinson disease. Eur J Neurol (in press)
Oeda T, et al. High risk factors for valvular heart disease from dopamine agonists in patients with Parkinson's disease. J Neural Trans (in press)